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  • Diabetes mellitus is an inability to regulate blood glucose caused by a loss of insulin production (Type I) or inadequate insulin supply or resistance (Type II). In cats, diabetes mellitus is most often type II. This type of diabetes usually results from obesity, creating insulin resistance. Cats with type II may be treated with oral medication, but some cats may ultimately require insulin injections. Diet is also important. This article discusses various treatments and monitoring regimens.

  • Diabetic ketoacidosis is a medical emergency that occurs when there is not enough insulin, or the available insulin isn’t effective enough to control blood sugar (glucose) levels. Your veterinarian needs to perform appropriate tests to diagnose this disease, as similar signs can occur with other medical conditions. Treatment involves hospitalization with IV fluids, short-acting insulin and electrolyte replacement. The most important step in prevention is ensuring careful insulin dosing and disease monitoring.

  • Cats with diabetes have the potential to go into remission where they may no longer need to receive insulin. Factors that can affect the likelihood of remission include the type of insulin given, your cat's diet, and how long your cat has been diabetic. It is important to recognize the signs of hypoglycemia, as they may be your first indication of remission.

  • The diaphragm is the muscular partition that separates the abdomen and the chest. Tearing or disruption of this thin muscle is called a diaphragmatic hernia or diaphragmatic rupture. The most common cause of diaphragmatic hernia is blunt force trauma.

  • Diarrhea is a symptom of an underlying problem that may be minor or very serious. Some cases may resolve on their own or with minimal treatment, while other cases require in-depth diagnostic testing and more aggressive treatment to address the underlying condition. The possible causes, diagnostic tests, and treatment protocols for diarrhea in cats are numerous and they are explained in this handout.

  • If your cat is having diarrhea, please complete this questionnaire as accurately as possible before your appointment. This information will be very helpful to your veterinarian in determining the cause of diarrhea.

  • Diazepam is given by mouth, injection, or into the rectum and is used off label to treat anxiety, seizures, tense muscles, or decreased appetite. Give as directed by your veterinarian. Side effects include sleepiness, increased appetite, incoordination, weakness, agitation, drooling, and aggression. Do not give to cats by mouth, and do not use in pets that are allergic to it or other benzodiazepines, or in pets with severe liver disease. If a negative reaction occurs, please call your veterinary office.

  • Diazoxide is given by mouth and is used off label to treat low blood sugar associated with insulin-producing tumors of the pancreas. Give as directed by your veterinarian. Common side effects include drooling, lack of appetite, vomiting, and diarrhea. Do not use in pets that are allergic to it or thiazide diuretics, or in pets with low blood sugar due to anything other than a tumor. If a negative reaction occurs, please call your veterinary office.

  • Diclofenac ophthalmic is a topical nonsteroidal anti-inflammatory medication used to treat inflammatory eye conditions in cats, dogs, rabbits, avian species, and other animals. Diclofenac ophthalmic comes in liquid drop form.

  • Digestive lubricants and hairball gels (e.g., Laxatone®) are oil-based lubricants that are given as supplements to help prevent and eliminate hairballs in cats. They come in oral gel format and are available in several flavors.